Lymphoma in pregnancy

A pregnat women and a green ribbon, the sign for the diagnosis of a lymphoma.

This section is only updated periodically, may not be complete, and does not replace a search for the most current available data and literature!

How I treat lymphoma in pregnancyComprehensive review of the management of lymphoma during pregnancy and key considerationsDunleavy K, McLintock C. How I treat lymphoma in pregnancy. Blood. 2020 Nov 5;136(19):2118-2124. https://pubmed.ncbi.nlm.nih.gov/32797210/
Hematological malignancies and pregnancy: a final report of 84 children who received chemotherapy in utero.In a cohort of 84 children born to mothers with hematological malignancies (29 acute leukemia, 26 Hodgkin’s disease, 29 non-Hodgkin lymphoma), 38 were exposed to chemotherapy during the first trimester. After a median follow-up of 18 years, no increased risk of mortality, malformations, somatic or psychiatric illness, or learning disabilities was observed. Notably, no cases of leukemia or lymphoma occurred.Avilés A, Neri N. Hematological malignancies and pregnancy: a final report of 84 children who received chemotherapy in utero. Clin Lymphoma. 2001 Dec;2(3):173-7.https://pubmed.ncbi.nlm.nih.gov/11779294/
Maternal and neonatal outcomes in 80 patients diagnosed with non-Hodgkin lymphoma during pregnancy: results from the International Network of Cancer, Infertility and Pregnancy. This report includes 54 patients treated with R-CHOP and several individual cases of rarer lymphomas. Findings include increased rates of prematurity (both iatrogenic and due to premature rupture of membranes), 44% small-for-gestational-age (SGA) infants, three cases of neonatal infection (one associated with neonatal neutropenia), and one case of reversible cardiomyopathy.Maggen C, et al. International Network on Cancer Infertility Pregnancy (INCIP). Maternal and neonatal outcomes in 80 patients diagnosed with non-Hodgkin lymphoma during pregnancy: results from the International Network of Cancer, Infertility and Pregnancy. Br J Haematol. 2021 Apr;193(1):52-62. https://pubmed.ncbi.nlm.nih.gov/32945547/
Obstetric and maternal outcomes in patients diagnosed with Hodgkin lymphoma during pregnancy: a multicentre, retrospective, cohort study.In a cohort of 72 women who received antenatal chemotherapy, maternal outcomes were comparable to those of non-pregnant individuals. There was a higher incidence of preterm contractions and premature rupture of membranes (PROM). While the overall rate of small-for-gestational-age (SGA) infants was not increased, neonates exposed to chemotherapy had lower birth weights.Maggen C, et al. International Network on Cancer, Infertility and Pregnancy. Obstetric and maternal outcomes in patients diagnosed with Hodgkin lymphoma during pregnancy: a multicentre, retrospective, cohort study. Lancet Haematol. 2019 Nov;6(11):e551-e561. https://pubmed.ncbi.nlm.nih.gov/31564649/
Risk of early-onset breast cancer among women exposed to thoracic computed tomography in pregnancy or early postpartum.No increased risk of early-onset breast cancer was observed after CT or V/Q scan during pregnancy; however, the risk of late-onset breast cancer remains unknown.Burton KR, Park AL, Fralick M, Ray JG. Risk of early-onset breast cancer among women exposed to thoracic computed tomography in pregnancy or early postpartum. J Thromb Haemost. 2018 May;16(5):876-885. https://pubmed.ncbi.nlm.nih.gov/29450965/

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